ISSN 2149-5807 | E-ISSN 2149-6048
Original Article
The relationship of serum Pentraxin-3 with peripheral arterial disease
1 Department of Emergency Medicine, Ankara Training and Research Hospital, Ankara, Turkey  
2 Department of Emergency Medicine, Ordu University Training and Research Hospital, Ordu, Turkey  
3 Department of Nutrition and Dietetics, Karadeniz Technical University School of Health Sciences, Trabzon, Turkey  
4 Department of Emergency Medicine, Karadeniz Technical University School of Medicine, Trabzon, Turkey  
5 Program of Medical Laboratory Techniques, Vocational School of Health Sciences, Karadeniz Technical University, Trabzon, Turkey  
6 Department of Cardiovascular Surgery, Ahi Evren Thoracic and Cardiovascular Surgery Training and Research Hospital, Trabzon, Turkey  
7 Department of Cardiovascular Surgery, Karadeniz Technical University School of Medicine, Trabzon, Turkey  
8 Department of Medical Biochemistry, Karadeniz Technical University School of Medicine, Trabzon, Turkey  
9 Public Hospitals Association Bakırköy General Secretaria, İstanbul, Turkey  
10 Department of Emergency Medicine, Ufuk University School of Medicine, Dr. Rıdvan Ege Education and Research Hospital, Ankara,Turkey  
Eurasian J Emerg Med ; : -
DOI: 10.5152/eajem.2017.06977
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Key Words: Atherosclerosis, inflammation, pentraxin-3, peripheral arterial disease

Aim: Since atherosclerosis is a chronic inflammatory process associated with with peripheral artery disease, the inflammatory marker pentraxin might be expected to increase in peripheral artery disease (PAD).

Materials and methods: This cross-sectional clinical study was performed at the tertiary university hospital emergency department and cardiovascular surgery departments in Turkey. The purpose was to determine the value of pentraxin-3 (PTX3) in the diagnosis of PAD. This study was performed with 43 symptomatic patients aged over 18 and diagnosed with PAD.

Results: Median PTX3 in the control group was 1.027 (25-75th percentile: 0.395- 2.902), and 0.585 (25-75th percentiles: 0.406-5.467) in patients with PAD (p: 0.913). Comparison of PTX3 with Ankle brachial index (ABI) values revealed a weak and non-significant correlation (rho: 0.016, p: 0.886). Analysis of PTX3 values with other parameters (age, systolic and diastolic blood pressure, heart rate, respiratory rate, temperature and spO2) revealed no significant correlation with any of the other parameters.

Conclusion: Our findings indicate that PTX3 levels cannot be used as a marker in patients with peripheral artery disease, a chronic process.

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