ISSN 2149-5807 | E-ISSN 2149-6048
Original Article
Diagnostic Value of Bedside Brain Natriuretic Peptide Measurement in Patients with Head Trauma
1 Etlik İhtisas Eğitim ve Araştırma Hastanesi, Acil Tıp Kliniği, Ankara, Türkiye  
2 Department of Emergency Medicine, Faculty of Medicine, Erciyes University, Kayseri, Turkey  
3 Fırat Üniversitesi, Tıp Fakültesi, Nöroşirürji Ana Bilim Dalı, Elazığ  
4 Fırat Üniversitesi, Tıp Fakültesi, Acil Tıp Ana Bilim Dalı, Elazığ  
5 Fırat Üniversitesi, Tıp Fakültesi, Biyokimya Ana Bilim Dalı, Elazığ  
6 Fırat Üniversitesi, Tıp Fakültesi, Radyoloji Ana Bilim Dalı, Elazığ  
Eurasian J Emerg Med 2010; 9: 21-25
DOI: 10.4170/JAEM.2009.93823
Key Words: Brain natriuretic peptide, head trauma, cranial CT, emergency department

BACKGROUND: Brain natriuretic peptide (BNP) is secreted by cardiac

ventricles in response to increased wall stress and intraventricular volume

but it was showed that there was some immunoreactivity of BNP in the

human brain including cerebral cortex, thalamus, pons, and cerebellum.


AIM: The aim of this study is to investigate the diagnostic value of bedside

measurement of BNP that is used in order to predict the presence of

intracranial pathologies in patients with head trauma.


MATERIALS AND METHODS: This study was performed prospectively

with head trauma patients. Bedside BNP measurements and cranial computed

tomography (CT) scans were performed in these patients.


RESULTS: The mean BNP level of 23 patients with pathologic cranial CT

scan was 16.16±15.8 pg/mL and the mean BNP level of 17 patients with

normal cranial CT scan was 5.78±3.0 pg/mL. It was 6.91±3.2 pg/mL in the

control group. The mean BNP level of patients with pathological cranial

CT was significantly higher than mean BNP levels of patients with normal

cranial CT and patients in the control group (p<0.01)


CONCLUSION: We think that BNP levels over 10 pg/mL values without

known causes of BNP increase may be effective and specific to detect

intracranial pathologies in head trauma patients.

Key Words
Editor’s Corner
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