ISSN 2149-5807 | E-ISSN 2149-6048
Original Article
Eff ect of Caff eic Acid Phenetyl Ester on Malondialdehyde Levels in Spinal Cord Injury in Rats
1 Department of Emergency Medicine, Ankara Atatürk Training and Research Hospital, Ankara, Turkey  
2 Department of Biochemistry, Ankara Atatürk Training and Research Hospital, Ankara, Turkey  
3 Ankara Ataturk Training and Research Hospital, Department of Emergency, Turkey  
4 Etlik İhtisas Eğitim ve Araştırma Hastanesi, Acil Tıp Kliniği, Ankara, Türkiye  
Eurasian J Emerg Med 2010; 9: 121-123
DOI: 10.4170/jaem.2010.02419
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Key Words: Caff eic acid phenethyl ester, spinal cord injury, malondialdehyde
Abstract

Objective: The aim of this study was to investigate the eff ects of caff eic acid

phenethyl ester on prevention of secondary damage in spinal cord injury

through determination of malondialdehyde levels in rats.

 

Materials and Methods: Thirty adult Wistar albino rats were randomized into

three groups. Spinal cord injury was performed by the weight-drop model.

Group 1 (control) underwent laminectomy followed by spinal cord injury and

received no medication. Group 2 underwent laminectomy followed by spinal

cord injury and received caff eic acid phenethyl ester (10 micromol/kg).

Group 3 underwent laminectomy followed by spinal cord injury and received

methylprednisolone (30 mg/kg) intraperitoneally. Twenty four hours later,

blood samples were obtained, then serum malondialdehyde levels were determined

and results were compared.

 

Results: Malondialdehyde levels in the control group was higher than the caffeic

acid phenethyl ester and methylprednisolone groups (respectively Group

1 and 2 p <0.003 Group 1 and 3 p<0.001). Furthermore,malondialdehyde levels

in the methylprednisolone group were lower than the caff eic acid phenethyl

ester group (Grup 2 ve 3 p<0.036).

 

Conclusion: In our study, caff eic acid phenethyl ester decreased MDA levels

compared to the control group, however the lowest MDA levels were determined

in the methylprednisolone group. Based on these results, , caff eic acid

phenethyl ester may be another neuroprotective agent in spinal cord injury

in addition to methylprednisolone.

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