The Diagnostic Value of SCUBE1 in Unstable Angina Pectoris Patients
Clinic of Emergency Medicine, Bağcılar Training and Research Hospital, İstanbul, Turkey
Department of Emergency Medicine, Bezmialem Vakif University School of Medicine, İstanbul, Turkey
Clinic of Emergency Medicine, Ümraniye Training and Research Hospital, İstanbul, Turkey
Department of Biochemistry, Bezmialem Vakif University School of Medicine, İstanbul, Turkey
Department of Cardiology, Bezmialem Vakif University School of Medicine, İstanbul, Turkey
Clinic of Cardiology, Siyami Ersek Thoracic and Cardiovascular Surgery Hospital, İstanbul, Turkey
Eurasian J Emerg Med 2016; 15: 167-171
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Key Words: Acute coronary syndrome, unstable angina pectoris, SCUBE1
Aim: Signal peptide complement C1r/C1s, Uegf, and Bmp1-epidermal growth factor-like domain-containing protein 1 (SCUBE1) has been used in research as a biomarker in acute coronary syndrome (ACS). The aim of this study is to determine if SCUBE1 and routine laboratory parameters are effective in distinguishing the patients presenting with clinical symptoms of unstable angina pectoris (USAP) from the patients who have non-ST-segment elevated myocardial infarction (NSTEMI) and non-cardiac chest pain patients (NCCP).
Materials and Methods: The study group consisted of patients having chest pain or those suspected of having an ACS complaint. The study consisted of 5 groups of 185 patients with USAP, NSTEMI, segment elevation myocardial infarction (STEMI), or NCCP, and a control group of 45 healthy patients (CG). The study was conducted according to the American Heart Association (AHA) guidelines.
Results: There was no statistical difference between the patient groups and CG in terms of SCUBE1 (p=0.650). The Troponin I value was significantly lower in the USAP group than the STEMI and NSTEMI groups (p<0.001). There was no difference among the sub-groups of USAP in terms of the SCUBE1, GENSINI, and the GRACE scores (p=0.485, 0.932, 0.585, respectively).
Conclusion: SCUBE1 was not diagnostic for USAP, NSTEMI, and STEMI. Further studies to understand the value of SCUBE1 in ACS are needed.