ISSN 2149-5807 | E-ISSN 2149-6048
Original Article
Diagnostic Value of Cyclophilin A in Acute Ischemic Stroke
1 Department of Emergency Medicine, Karadeniz Technical University School of Medicine, Trabzon, Turkey  
2 Clinic of Emergency Medicine, Manisa State Hospital, Manisa, Turkey  
3 Department of Biochemistry, Karadeniz Technical University School of Medicine, Trabzon, Turkey  
4 Department of Chemical and Chemical Processing Technology, Ordu University School of Ulubey Vocational, Ordu, Turkey  
5 Clinic of Emergency Medicine, Gümüşhane State Hospital, Gümüşhane, Turkey  
6 Department of Chest Diseases, Recep Tayyip Erdoğan University School of Medicine, Rize, Turkey  
Eurasian J Emerg Med 2017; 16: 54-56
DOI: 10.5152/eajem.2017.35119
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Key Words: Acute ischemic stroke, cyclophilin A, emergency department
Abstract

Aim: The early diagnosis and treatment of patients presenting to the emergency department symptoms of stroke can significantly reduce mortality and morbidity rates associated with it. This study aimed to investigate the diagnostic value of serum yclophilin A levels in our study group who presented to the emergency department with symptoms of acute ischemic stroke.

 

Materials and Methods: In total, 114 patients diagnosed with acute ischemic stroke between October 2013 and October 2014 and a control group of 66 healthy volunteers were included. Cyclophilin A levels in the patient and control groups were compared. 

 

Results:  The median cyclophilin A levels in the patient and control groups measured at the time of presentation were 13.47 (11.97–17.92) ng/mL and 11.54 (8.48–16.22) ng/mL, respectively. These levels were significantly higher in the patient group than in the control group (p<0.05). 

 

Conclusion: Plasma cyclophilin A levels were significantly higher in the patient group than in the control group.  

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